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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: J Proteome Res. 2017 Mar 21;16(4):1391–1400. doi: 10.1021/acs.jproteome.6b00470

Table 2.

Drugs Most Active against Claudin-Low Cell Linesa

p value drug target
5.7 × 10−5 GSK461364 polo-like kinase, active in M phase
0.00031 docetaxel mitotic spindle
0.00065 vinorelbine mitotic spindle
0.0025 paclitaxel mitotic spindle
0.0036 etoposide topoisomerase
0.0039 ibandronate inhibits bone resorption
0.0051 bosutinib tyrosine kinases
0.0052 ixabepilone mitotic spindle
0.019 GSK923295 centromere-associated protein
0.022 PF_3814735 Aurora kinase, chromatid segregation
0.023 lestaurtinib tyrosine kinases
0.027 TCS2312 checkpoint kinase inhibitor
0.028 irinotecan topoisomerase
0.031 XRP44X ras-net (ELK3)
0.033 sunitinib receptor tyrosine kinases
0.035 cisplatin DNA
0.043 GSK1070916 Aurora kinase, chromatid segregation
0.049 IKK_16 IkB kinase
a

For each drug, two-sample t tests were performed comparing drug sensitivity of the claudin-low cell lines to the others. The results were sorted on the p values.