Table 3.
Significant Gene Ontology (GO) terms of hyper-methylated genes in NJCMS5A
| GO accession | Term type | Description | DMR _ item | BG _ item | P _ value |
|---|---|---|---|---|---|
| GO:0019058 | BP | viral infectious cycle | 6 | 364 | 0.0022802 |
| GO:0006011 | BP | UDP-glucose metabolic process | 1 | 1 | 0.0036546 |
| GO:0015977 | BP | carbon fixation | 2 | 25 | 0.0037648 |
| GO:0016042 | BP | lipid catabolic process | 3 | 109 | 0.0075620 |
| GO:0044403 | BP | symbiosis, encompassing mutualism through parasitism | 8 | 789 | 0.0086707 |
| GO:0071704 | BP | organic substance metabolic process | 76 | 16,860 | 0.0089794 |
| GO:0044419 | BP | interspecies interaction between organisms | 8 | 796 | 0.0091147 |
| GO:0006099 | BP | tricarboxylic acid cycle | 2 | 40 | 0.0094446 |
| GO:0000723 | BP | telomere maintenance | 5 | 350 | 0.0094633 |
| GO:0032200 | BP | telomere organization | 5 | 350 | 0.0094633 |
| GO:0060249 | BP | anatomical structure homeostasis | 5 | 350 | 0.0094633 |
| GO:0019067 | BP | viral assembly, maturation, egress, and release | 3 | 130 | 0.0121930 |
| GO:0009060 | BP | aerobic respiration | 2 | 46 | 0.0123550 |
| GO:0016032 | BP | viral process | 7 | 725 | 0.0175200 |
| GO:0044238 | BP | primary metabolic process | 72 | 16,245 | 0.0190260 |
| GO:0009225 | BP | nucleotide-sugar metabolic process | 1 | 6 | 0.0217300 |
| GO:0034219 | BP | carbohydrate transmembrane transport | 1 | 6 | 0.0217300 |
| GO:0071806 | BP | protein transmembrane transport | 2 | 66 | 0.0244210 |
| GO:0006367 | BP | transcription initiation from RNA polymerase II promoter | 2 | 67 | 0.0251130 |
| GO:0030150 | BP | protein import into mitochondrial matrix | 1 | 7 | 0.0253060 |
| GO:0044764 | BP | multi-organism cellular process | 7 | 785 | 0.0256590 |
| GO:0015074 | BP | DNA integration | 2 | 69 | 0.0265210 |
| GO:0044237 | BP | cellular metabolic process | 67 | 15,179 | 0.0286360 |
| GO:0072519 | BP | parasitism | 1 | 9 | 0.0324180 |
| GO:0018149 | BP | peptide cross-linking | 1 | 10 | 0.0359550 |
| GO:0006464 | BP | cellular protein modification process | 19 | 3357 | 0.0370220 |
| GO:0036211 | BP | protein modification process | 19 | 3357 | 0.0370220 |
| GO:0006468 | BP | protein phosphorylation | 15 | 2522 | 0.0427720 |
| GO:0019068 | BP | virion assembly | 2 | 90 | 0.0430940 |
| GO:0043170 | BP | macromolecule metabolic process | 57 | 12,853 | 0.0449750 |
| GO:0043412 | BP | macromolecule modification | 20 | 3665 | 0.0451580 |
| GO:0032940 | BP | secretion by cell | 3 | 221 | 0.0477090 |
| GO:0046903 | BP | secretion | 3 | 221 | 0.0477090 |
| GO:0006807 | BP | nitrogen compound metabolic process | 41 | 8794 | 0.0487850 |
| GO:0000079 | BP | regulation of cyclin-dependent protein serine/threonine kinase activity | 1 | 14 | 0.0499750 |
| GO:0071900 | BP | regulation of protein serine/threonine kinase activity | 1 | 14 | 0.0499750 |
| GO:0016592 | CC | mediator complex | 4 | 183 | 0.0046636 |
| GO:0036126 | CC | sperm flagellum | 1 | 2 | 0.0072960 |
| GO:0097223 | CC | sperm part | 1 | 2 | 0.0072960 |
| GO:0097228 | CC | sperm principal piece | 1 | 2 | 0.0072960 |
| GO:0005654 | CC | nucleoplasm | 5 | 384 | 0.0136830 |
| GO:0044451 | CC | nucleoplasm part | 5 | 384 | 0.0136830 |
| GO:0071203 | CC | WASH complex | 2 | 61 | 0.0210820 |
| GO:0033644 | CC | host cell membrane | 2 | 67 | 0.0251130 |
| GO:0044218 | CC | other organism cell membrane | 2 | 67 | 0.0251130 |
| GO:0044279 | CC | other organism membrane | 2 | 67 | 0.0251130 |
| GO:0044441 | CC | cilium part | 1 | 7 | 0.0253060 |
| GO:0036128 | CC | catSper complex | 1 | 9 | 0.0324180 |
| GO:0030658 | CC | transport vesicle membrane | 2 | 87 | 0.0405380 |
| GO:0019031 | CC | viral envelope | 4 | 354 | 0.0413760 |
| GO:0036338 | CC | viral membrane | 4 | 354 | 0.0413760 |
| GO:0005891 | CC | voltage-gated calcium channel complex | 1 | 13 | 0.0464890 |
| GO:0034704 | CC | calcium channel complex | 1 | 13 | 0.0464890 |
| GO:0004675 | MF | transmembrane receptor protein serine/threonine kinase activity | 2 | 18 | 0.0019525 |
| GO:0008964 | MF | phosphoenolpyruvate carboxylase activity | 2 | 20 | 0.0024130 |
| GO:0008234 | MF | cysteine-type peptidase activity | 5 | 273 | 0.0033820 |
| GO:0019199 | MF | transmembrane receptor protein kinase activity | 2 | 25 | 0.0037648 |
| GO:0001076 | MF | RNA polymerase II transcription factor binding transcription factor activity | 4 | 180 | 0.0043995 |
| GO:0001104 | MF | RNA polymerase II transcription cofactor activity | 4 | 180 | 0.0043995 |
| GO:0017111 | MF | nucleoside-triphosphatase activity | 17 | 2371 | 0.0059866 |
| GO:0000988 | MF | protein binding transcription factor activity | 5 | 320 | 0.0065718 |
| GO:0004611 | MF | phosphoenolpyruvate carboxykinase activity | 2 | 34 | 0.0068906 |
| GO:0016462 | MF | pyrophosphatase activity | 17 | 2410 | 0.0070057 |
| GO:0004197 | MF | cysteine-type endopeptidase activity | 4 | 221 | 0.0089745 |
| GO:0016818 | MF | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 17 | 2498 | 0.0098272 |
| GO:0000989 | MF | transcription factor binding transcription factor activity | 4 | 228 | 0.0099793 |
| GO:0003712 | MF | transcription cofactor activity | 4 | 228 | 0.0099793 |
| GO:0016787 | MF | hydrolase activity | 38 | 7372 | 0.0141010 |
| GO:0016817 | MF | hydrolase activity, acting on acid anhydrides | 17 | 2626 | 0.0154860 |
| GO:0005516 | MF | calmodulin binding | 2 | 56 | 0.0179520 |
| GO:0000149 | MF | SNARE binding | 1 | 5 | 0.0181410 |
| GO:0019905 | MF | syntaxin binding | 1 | 5 | 0.0181410 |
| GO:1,901,363 | MF | heterocyclic compound binding | 59 | 12,823 | 0.0194820 |
| GO:0097159 | MF | organic cyclic compound binding | 59 | 12,831 | 0.0197370 |
| GO:0004386 | MF | helicase activity | 9 | 1116 | 0.0217290 |
| GO:0004308 | MF | exo-alpha-sialidase activity | 1 | 6 | 0.0217300 |
| GO:0004683 | MF | calmodulin-dependent protein kinase activity | 1 | 6 | 0.0217300 |
| GO:0016997 | MF | alpha-sialidase activity | 1 | 6 | 0.0217300 |
| GO:0034062 | MF | RNA polymerase activity | 5 | 448 | 0.0247360 |
| GO:0070403 | MF | NAD+ binding | 1 | 7 | 0.0253060 |
| GO:0016779 | MF | nucleotidyltransferase activity | 7 | 785 | 0.0256590 |
| GO:0003676 | MF | nucleic acid binding | 33 | 6489 | 0.0271790 |
| GO:0003852 | MF | 2-isopropylmalate synthase activity | 1 | 8 | 0.0288680 |
| GO:0008083 | MF | growth factor activity | 2 | 73 | 0.0294300 |
| GO:0003899 | MF | DNA-directed RNA polymerase activity | 4 | 319 | 0.0299720 |
| GO:0003677 | MF | DNA binding | 23 | 4224 | 0.0332160 |
| GO:0016298 | MF | lipase activity | 3 | 197 | 0.0359010 |
| GO:0004325 | MF | ferrochelatase activity | 1 | 10 | 0.0359550 |
| GO:0038023 | MF | signaling receptor activity | 4 | 347 | 0.0389240 |
| GO:0047750 | MF | cholestenol delta-isomerase activity | 1 | 11 | 0.0394790 |
| GO:0003678 | MF | DNA helicase activity | 6 | 693 | 0.0423700 |
| GO:0016863 | MF | intramolecular oxidoreductase activity, transposing C = C bonds | 1 | 12 | 0.0429910 |
| GO:0046915 | MF | transition metal ion transmembrane transporter activity | 3 | 221 | 0.0477090 |
| GO:0046789 | MF | host cell surface receptor binding | 1 | 14 | 0.0499750 |
BP biological process; CC cellular component; MF molecular functional; DMR differentially methylated region; BG: background