Table 6.
Patients’ demographic data and clinical characteristics at admission to ICU grouped according to gender
| Male (n = 36) | Female (n = 10) | p value | |
|---|---|---|---|
| Age (years) | 52.9 ± 12.6 | 67.0 ± 17.9 | 0.007 |
| Hospital mortality | 25/36 (69.4%) | 9/10 (90%) | (0.252) |
| SOFA score | 12.2 ± 4.4 | 13.0 ± 4.2 | (0.618) |
| MELD score | 30.5 (24–39.8) | 27 (16.8–37.8) | (0.431) |
| Child–Pugh score | 12 (10.3–13) | 11.5 (9–13.3) | (0.666) |
| ACTH (pg/ml) | 19.1 (9.8–32.7) | 22 (6.3–47.9) | (0.929) |
| Baseline cortisol (nmol/L) | 675 (428–1086) | 975 (680–1260) | (0.132) |
| Peak cortisol (nmol/L) | 927 (697–1381) | 1338 (955–1639) | (0.088) |
| Cortisol increment (nmol/L) | 221 (112–353) | 240 (167–466) | (0.432) |
| Baseline DHEAS (nmol/L) | 704 (437–1140) | 824 (510–1428) | (0.409) |
| Peak DHEAS (nmol/L) | 877 (491–1263) | 961 (510–1692) | (0.489) |
| DHEAS increment (nmol/L) | 89.6 (25.8–171.7) | 70.6 (0–245.7) | (0.957) |
| Baseline DHEAS/cortisol ratio | 1.46 ± 1.16 | 1.37 ± 1.68 | (0.843) |
| IL-6 (pg/ml) | 318 (150–855) | 482 (310–1288) | (0.404) |
| TNF-α (pg/ml) | 31 (11.2–78) | 47 (39–52.5) | (0.208) |
| CIRCI | 22/36 (61.1%) | 6/10 (60%) | (1.000) |
Data presented as mean ± SD, number (percentage), or median (interquartile range)
SOFA Sequential Organ Failure Assessment, MELD Model for End-Stage Liver Disease, ACTH adrenocorticotropic hormone, DHEAS dehydroepiandrosterone sulfate, IL-6 interleukin-6, TNF-α tumor necrosis factor alpha, CIRCI critical illness-related corticosteroid deficiency, ICU intensive care unit