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. Author manuscript; available in PMC: 2018 Mar 17.
Published in final edited form as: Circ Res. 2017 Mar 17;120(6):923–940. doi: 10.1161/CIRCRESAHA.116.309140

Figure 1.

Figure 1

A Outline of human heart development. The X axis displays days of human and mouse gestation. B The spectrum of congenital heart disease from mild to severe. The lesions indicated as “severe” are expected to require intervention in the first year of life. ASD-Atrial Septal Defect, VSD-Ventricular Septal Defect, CoA- Coarctation of the Aorta, TOF-Tetralogy of Fallot, TGA- Transposition of the Great Arteries, HLHS- Hypoplastic Left Heart Syndrome. Classes of CHD based on proposed developmental-genetic mechanisms are indicated in parentheses; LVO-Left Ventricular Outflow Obstruction, CTD- Cono-Truncal Defect, HTX- Heterotaxy. C Genetic causes of CHD identified to date.