Table 3.
Risk factors related to TSS in stage I EOC patients of reproductive age
| Variables | DOD | 5 year-OS% | p valuea | p valueb | HR(95%CI) | |
|---|---|---|---|---|---|---|
| Yes | No | |||||
| Type of surgery | 0.048 | 0.469 | 0.38(0.03–5.34) | |||
| RS (reference) | 7 | 49 | 87.2 | |||
| FSS | 1 | 51 | 97.3 | |||
| Age | 0.030 | 0.690 | 1.81(0.10–33.40) | |||
| ≤ 30 years (reference) | 1 | 54 | 97.6 | |||
| > 30 years | 7 | 46 | 86.3 | |||
| Tumor size | 0.495 | |||||
| ≤ 12 cm (reference) | 5 | 50 | 90.1 | |||
| > 12 cm | 3 | 50 | 93.9 | |||
| Histology | 0.074 | |||||
| Mucinous | 1 | 51 | 97.5 | 0.195 | 11.38(0.29–450.86) | |
| Serous | 1 | 8 | 88.9 | 0.235 | 4.46(0.38–52.35) | |
| Endometrioid | 2 | 25 | 92.6 | 0.078 | 7.80(0.80–76.36) | |
| CCC (reference) | 4 | 16 | 78.5 | |||
| Grade | < 0.001 | 0.007 | 38.92(2.68–565.45) | |||
| G1-2 (reference) | 2 | 82 | 97.3 | |||
| G3/CCC | 6 | 18 | 73.9 | |||
| FIGO stage | 0.314 | |||||
| IA-B (reference) | 1 | 35 | 97.2 | |||
| IC1 | 6 | 49 | 88.6 | |||
| IC2-3 | 1 | 16 | 90.0 | |||
| Pretreatment tumor markers | 0.430 | |||||
| Normal (reference) | 3 | 52 | 94.5 | |||
| Elevated | 5 | 48 | 89.0 | |||
| EAOC | 0.024 | 0.343 | 2.34(0.40–13.59) | |||
| No (reference) | 4 | 83 | 95.1 | |||
| Yes | 4 | 17 | 79.6 | |||
RS radical surgery, FSS fertility-sparing surgery, TSS tumor-specific survival, EOC epithelial ovarian cancer, CCC clear-cell carcinoma, EAOC endometriosis-associated ovarian cancer, DOD dead of the recorded disease, HR hazard ratios, CI confidence intervals
aLog-rank test
bCox proportional hazards model