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Number of individuals and number of clusters required for a cluster randomised crossover (CRXO), cluster randomised controlled trial (CRCT) and individually randomised controlled trial (IRCT) trial with ρ = 0.038 for all designs and specified η for CRXO design
| Number of required individuals | Number of required ICUs | |
|---|---|---|
| CRXO | ||
| ρ = 0.038, η = 0.032 | 10,564 | 27 |
| ρ = 0.038, η = 0.010 | 30,433 | 77 |
| CRCT | 39,065 | 196 |
| IRCT | 4345 | 22 |
ICU intensive care unit
