Table 1.

Reported cases of antibiotic-associated hemorrhagic colitis due to the second-line therapy for Helicobacter pylori eradication

Age	Gender	Symptoms	Onset	First-line therapy	Second-line therapy	Fecal bacterial culture	DLST	References
58	F	Abdominal pain, bloody diarrhea	8 days after starting eradication	CAM + AMPC + RPZ	MNZ 500 mg + AMPC 1500 mg + RPZ 20 mg	Pathogenic bacteria was not detected	Not described	#12
54	M	Abdominal pain, bloody diarrhea	7 days after starting eradication	CAM + AMPC + RPZ	MNZ 500 mg + AMPC 1500 mg + RPZ 20 mg	Pathogenic bacteria was not detected	Not described	#12
59	F	Abdominal pain, bloody diarrhea	9 days after starting eradication	CAM + AMPC + RPZ	MNZ 500 mg + AMPC 1500 mg + RPZ 20 mg	Pathogenic bacteria was not detected	Not described	#12
60	F	Abdominal pain, bloody diarrhea	9 days after starting eradication	CAM + AMPC + PPI	MNZ + AMPC + PPI	Klebsiella oxytoca	Not described	#13
50	M	Abdominal pain, hematochezia	6 days after starting eradication	CAM + AMPC + PPI	MNZ + AMPC + PPI	Not described	Not described	#13
65	F	Abdominal pain, hematochezia	8 days after starting eradication	CAM 800 mg + AMPC 1500 mg + LPZ 60 mg	MNZ 500 mg + AMPC 1500 mg + Vonoprazan 40 mg	Klebsiella oxytoca	Positive for both AMPC and MNZ	Present case

CAM clarithromycin, AMPC amoxicillin, MNZ metronidazole, RPZ rabeprazole, LPZ lansoprazole, PPI proton pump inhibitor