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. 2017 Aug 14;17:545. doi: 10.1186/s12885-017-3536-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Features of lymphoma occurrence in p53-deficient heterozygous mice induced by 37.5 mg/kg MNU. a Tumor frequency in mice administered MNU or citrate buffer. b Tumor frequencies in thymus and spleen of mice administered MNU. c Hematoxylin and eosin (H&E) staining of lymphoma in thymus. d H&E staining of lymphoma in spleen. e, f. Thymus (e) and spleen (f) lymphoma stained positive for CD3 (T-lymphocyte marker). g, h Thymus (g) and spleen (h) lymphoma stained negative for CD20 (B-lymphocyte marker). i, j Thymus (i) and spleen (j) lymphoma stained negative for CD68 (macrophage marker). Magnification ×200, scale bar = 100 μm