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. 2017 Aug 15;12(8):e0183025. doi: 10.1371/journal.pone.0183025

Fig 1. Targeted metabolic profiling of amines and methylarginines in human plasma from healthy donors and patients with sepsis.

Fig 1

Amine and methylarginine levels were measured using (A) UHPLC-MS/MS, LC-MS/MS and/or ELISA in the plasma of healthy donors and patients with sepsis at diagnosis (0 hours), 24 hours and 72 hours post diagnosis. Comparisons between levels of L-arginine from (B) UHPLC-MS/MS, LC-MS/MS and ELISA and (C) ADMA from LC-MS/MS and ELISA are shown at diagnosis (0 hours), 24 hours and 72 hours, post diagnosis. (D) Canonical pathways extracted from IPA software were based on an input of read outs comparing plasma levels of amines in healthy donors and patients with sepsis as a ratio. Data are ± SEM for n = 21 healthy donors and n = 38 patients with sepsis. Data was analysed by one-way ANOVA with Dunnett’s post-hoc test and Benjamini-Hochberg test with a false discovery rate of 0.05; *p<0.05.