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. 2017 Aug 10;12:5761–5779. doi: 10.2147/IJN.S142122

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© 2017 Lee et al. This work is published and licensed by Dove Medical Press Limited

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Caveolin-mediated endocytosis affects uptake of DEX-PEG-coated CNT in TNF-α-stimulated FLS.

Notes: (A, B) FLS and TNF-α-stimulated FLS were pretreated with 200 μM caveolin-mediated endocytosis inhibitor (GEN) for 30 min and then treated with 0.5 μg/mL DEX-Alexa 488-labeled PEG-coated CNT for 2 h. The fluorescence was visualized by confocal microscopy (×400) and densitometric analysis. Scale bar: 20 μm. The results are presented as mean ± SEM (n=10). ***P<0.001, as compared with GEN non-treated group in TNF-α-stimulated FLS.

Abbreviations: CNT, carbon nanotube; DEX, dexamethasone; FLS, fibroblast-like synoviocytes; GEN, genistein; PEG, polyethylene-glycol; SEM, standard error of the mean; TNF-α, tumor necrosis factor-α.