. Author manuscript; available in PMC: 2017 Aug 15.

Published in final edited form as: J Proteome Res. 2017 Jul 3;16(8):3009–3018. doi: 10.1021/acs.jproteome.7b00293

Table 1. IPA analysis of upstream regulators due to treatment.

IPA upstream regulators tool was used to determine proteins putatively up or down regulated based on the differential abundance of the proteins from the iTRAQ dataset. Activation z-score is used to represent the likelihood of a protein to be activated or inactivated based on A. full nutrients with CQ and IR treatment and B. no glucose with CQ and IR treatment.

A Full Nutrient with CQ and IR treatment

Upstream Regulator	Activation z-score
TP53	1.138
CDKN1A	1.000
TGFB1	−0.817
TP63	−0.927
MAPK9	−1.387
NUPR1	−1.387

B No Glucose with CQ and IR treatment

Upstream Regulator	Activation z-score

TP53	1.315
NUPR1	−0.632