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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Kidney Int. 2017 May 3;92(3):558–568. doi: 10.1016/j.kint.2017.02.033

Figure 3. Profibrogenic effect of miR-127-3p.

Figure 3

A and B: Masson’s trichrome staining of UUO kidneys in control mice, mice treated with the negative (scrambled) LNAs, and mice receiving complementary LNAs to miR-127 and miR-410. Ordinate shows the number of pixels corresponding to the detection of fibrotic areas. Horizontal lines above individual bars indicate p<0.05 between the corresponding groups. N=5 per each group of animals. Note that LNA to miR-127 mitigates fibrosis compared to both control groups, whereas LNA to miR-410 (another miR screen finding) is not effective, at least at the dose used.

C: Targets of miR-127-3p. TargetScan identifies these target gene promoters relevant to Wnt/β-catenin and Notch pathways. Note a remarkable overlap with proteomic findings. In red are components of main focus.