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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Kidney Int. 2017 May 3;92(3):558–568. doi: 10.1016/j.kint.2017.02.033

Fig. 4. Example of a dialog between the dysfunctional endothelium secreting semaphorin 7A and fibroblasts.

Fig. 4

A: Primary renal fibroblasts cultured in the presence of Sema-7A–Fc exhibit a 2-fold increase in prematurely senescent cells after only 48 h in culture.

B: A cartoon depicting the vicious circle between dysfunctional endothelial secretome containing, among others, semaphorin 7A, and fibroblasts, which develop premature senescence and release SASP in turn affecting endothelial cells.