Table 5.
Summary of pharmacokinetic parameters for the derivatized clopidogrel active metabolite (CAM-D), clopidogrel, and clopidogrel carboxylic acid metabolite from cats treated with a single oral dose of 18.75mg clopidogrel.
| Parameter (units) | CAM-D | Clopidogrel | Clopidogrel carboxylic acid | |||
|---|---|---|---|---|---|---|
|
|
|
|
||||
| Cat 1 | Cat 2 | Cat 1 | Cat 2 | Cat 1 | Cat 2 | |
| Cmax (ng/mL) | 39.0 | 16 | 134 | 144 | 3,300 | 2,900 |
| Tmax (h) | 1.5 | 2.0 | 2 | 0.7 | 2.0 | 1.5 |
| t1/2 (h) | 4.9 | 2.8 | 5.4 | 5.2 | 9.2 | 10.4 |
| AUClast (ng.h/mL) | 117 | 60 | 374 | 225 | 25,000 | 18,100 |
| AUCtotal (ng.h/mL) | 134 | 68 | 377 | 229 | 31,400 | 21,200 |
| Area extrapolated (%) | 12.3 | 12 | 0.8 | 1.8 | 19.6 | 14.6 |
Cmax, maximum concentration; Tmax, time taken to reach maximum concentration; t1/2, elimination half-life; AUClast, area under the plasma concentration-time curve from 0 to 24hrs; AUCtotal, area under the plasma concentration-time curve extrapolated to infinity.