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. Author manuscript; available in PMC: 2017 Oct 18.
Published in final edited form as: Mucosal Immunol. 2017 Feb 15;10(6):1504–1517. doi: 10.1038/mi.2017.9

Figure 7. IL-22 depletion inhibits DNA damage in mice chronically infected with Hh.

Figure 7

Uninfected 129RAG2−/− mice or mice infected with Hh for 10 weeks were treated either with depleting IL-22 Ab or a control Ab for the final week of the experiment. (A) Representative histological sections from the cecum were analyzed with indicated stains. (B) Graphs representing the percent of epithelial cells that were Ki67+ (top) or γH2AX+ (bottom), n=9. (C) Representative histological sections with indicated stains comparing localization of iNOS within epithelial cells (EPCAM) and macrophages (F4/80). Single channel stains of iNOS alone are provided to more clearly demonstrate the differential effects of IL-22 depletion on epithelial cells and macrophages. (D) The fraction of crypts that exhibited iNOS staining was compared (n=3-4).