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. 2017 Aug 14;8:955. doi: 10.3389/fimmu.2017.00955

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Copyright © 2017 Didié, Galla, Muppala, Dressel and Zimmermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of immunostimulatory capacity of parthenogenetic stem cell (pSC)-EHM generated from major histocompatibility complex (MHC)-matched or -mismatched pSC-derived cardiomyocytes and murine embryonic fibroblasts. Analysis of proliferation of splenocytes (A,C) and T-cells (B,D) after co-culture with engineered heart muscles (EHMs) containing MHC-matched (A,B) or -mismatched (C,D) pSC-derived cardiomyocytes and murine embryonic fibroblasts in presence or absence of IFN-γ. Spl., Splenocytes; Bl6, C57Bl/6J; DBA, DBA/2J (n = 3/group); MEF, murine embryonic fibroblasts.