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. 2017 Aug 14;11:151. doi: 10.3389/fnbeh.2017.00151

Figure 4.

Figure 4

Effects of AIE (5 g/kg, i.g., 2 days on/2 days off) exposure on DCX+ (A) Prox1+ (B) and parvalbumin (PV)+IR (C) expression in the hippocampal DG of male rat brain at P57 and P95. AIE exposure remarkably reduced Prox1+ (B, 15%) and PV+IR (C, 27%) expression at P57 compared with control group, and reduced DCX+ (A, 29%) and PV+IR (C, 28%) expression at P95. *p < 0.05, **p < 0.01 compared with control group. There was a significantly maturational decline with DCX+ (A, control: 49%; AIE: 56%), Prox1+ (B, control: 33%) or PV+IR (C, control: 29%; AIE: 29%) expression in control or AIE group. #p < 0.05, ##p < 0.01, ###p < 0.001 compared with control or AIE group at P57, respectively. The data were expressed as pixels of DCX+ (A) or the numbers of Prox1+ (B) or PV+IR (C) positive cells, each point is mean ± SEM per mm2 (n = 7~8/group). Right panels: DCX+IR expression in the granular cell layer of the hippocampal DG (Immunohistochemical staining, Bar scale = 50 μm).