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. 2017 Aug 14;11:151. doi: 10.3389/fnbeh.2017.00151

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Copyright © 2017 Liu and Crews.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of AIE (5 g/kg, i.g., 2 days on/2 days off) exposure on SOX2+ and Mash1+IR expression in the subventricular zone (SVZ) of male rat brain at P57 and P95. AIE exposure remarkably decreased SOX2+ (18%, A) and Mash1+IR (59%, B) at P95 compared with control group. *p < 0.05, **p < 0.01 compared with control group. There was a significant maturational decline with SOX2+ (A, control: 25%; AIE: 41%), and Mash1+IR (B, AIE: 56%) expression in control or AIE group. ^#p < 0.05, ^###p < 0.001 compared with control or AIE group at P57, respectively. The data were expressed as pixels of SOX2+ and Mash1+IR, each point is mean ± SEM per mm² (n = 7~8/group). Right panels: SOX2+ and Mash1+IR expression in the SVZ at P95 (Immunohistochemical staining, Bar scale = 100 μm on SOX2+IR; 50 μm on Mash1+IR).