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. 2017 Aug 14;8:978. doi: 10.3389/fimmu.2017.00978

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Copyright © 2017 Timóteo, Silva, da Silva, Catarino, Alves, Rodrigues Júnior, Roselino, Sales-Campos and Oliveira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The profile of cytokines, chemokines, and disease severity in patients with the endemic form of pemphigus foliaceus. (A) Stratification of fogo selvagem (FS) patients according to the extension of skin lesions. Levels of (B) IFN-γ, (C) IL-2, (D) IL-6, (E) IL-8, (F) IL-10, (G) IL-22, (H) CCL-5/RANTES, and (I) CCL-10/IP-10, from patients with the endemic form (FS) of pemphigus foliaceus without treatment (No treatment) compared to those taking immunosuppressive therapy with different degrees of lesions in skin (I-III). Lines represent median. *p < 0.05, Kruskal–Wallis test followed by Dunn’s test.