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. 2017 Aug 14;8:978. doi: 10.3389/fimmu.2017.00978

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Copyright © 2017 Timóteo, Silva, da Silva, Catarino, Alves, Rodrigues Júnior, Roselino, Sales-Campos and Oliveira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokine and chemokine interplay after treatment with immunosuppressant drugs. Levels of (A) IFN-γ, (B) IL-17, (C) IL-6, (D) IL-23, (E) IL-5, (F) IL-10, (G) IL-22, (H) IL-2, (I) TNF-α, (J) IL-12, (K) IL-15, (L) IL-33, (M) CXCL-8/IL-8, (N) CCL-2/MCP-1, (O) CCL-5/RANTES, (P) CCL-11/eotaxin-1, and (Q) CXCL-10/IP-10 from patients with the endemic form (fogo selvagem—FS) of pemphigus foliaceus under different conditions of treatment (no treatment, treated, and post-treatment). Lines represent median. *p < 0.05, Kruskal–Wallis test followed by Dunn’s test. (R) Radar plot representation of serum cytokine and chemokine profile of not treated (black lines), in treatment (light gray) and post-treatment (dark gray) FS patients. Data were obtained by calculating the ratio between the median concentrations of each cytokine in the pemphigus foliaceus (FS) patients under- or post-treatment versus the untreated group.