Table 1.
Dimm target genes that affect growth of NMJ and synaptic structures.
| Genes | Overexpression | RNAi or mutation | Reference |
|---|---|---|---|
| ACC (Acetyl-CoAcarboxylase) | – | Synaptic undergrowth | Valakh et al., 2012 |
| Adf1 (Adh transcription factor 1) | Increased bouton number | Reduced bouton number | DeZazzo et al., 2000 |
| ash2 (absent, small, or homeotic disks 2) | – | Pathfinding defect, reduced/abnormal synapses | Kraut et al., 2001 |
| CG11486 (polyA-nuclease related protein) | Pathfinding defect, excess/ectopic synapses | – | Kraut et al., 2001 |
| Chic (Chickadee) | – | Filopodia length reduced, axon extension reduced | Goncalves-Pimentel et al., 2011 |
| Csp (Cystein string protein) | – | Reduced bouton number, string length, fewer branches, terminal length | Bronk et al., 2005; Dawson-Scully et al., 2007 |
| Got2 (Glutamate oxaloacetate transaminase 2) | – | Reduced glutamate level, increased post-synaptic receptor area and more GluRs | Featherstone et al., 2002 |
| Gs2 (Glutamine synthetase) | – | Fewer post-synaptic GluRs | Featherstone et al., 2002 |
| Mbl (Muscleblind) | – | Synaptic undergrowth, synaptic retraction and axonal transport defect | Valakh et al., 2012 |
| Pdk (Pyruvate dehydrogenase kinase) | Excess synapses, ectopic branches and axonal pathfinding errors | – | Kraut et al., 2001 |
| sigA (Sluggish A) | – | Synaptic apposition, retraction and axonal transport defects | Valakh et al., 2012 |
| Spi (Spitz) | – | Pathfinding defects, abnormal/reduced synapses | Kraut et al., 2001 |
| Sta (Stubarista) | – | Synaptic apposition defect | Valakh et al., 2012 |
| Vha55 (Vacuolar H+-ATPase 55 kD subunit) | – | Reduced Evi exosome release | Koles et al., 2012 |
These genes were mined from a larger set in Hadzic et al. (2015).