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. 2017 Aug 15;7:8197. doi: 10.1038/s41598-017-08572-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thinner functionalized electrospun PCL microfibers (2 PP) were more effective for the muscle cell growth and differentiation. (A,B) Relative expression of IGF1, PI3K, AKT, mTOR and myostatin of cells and muscle tissues. C, Representative western blotting of PI3K, AKT and myostatin of muscle tissues from in vivo experiments. ^{*, #, $} p < 0.05 and **p < 0.01 as indicated.