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. 2017 Aug 15;7:8186. doi: 10.1038/s41598-017-07569-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signal Kinetics of TEC. (A) The signal kinetics with the combination of β9-L73J (12.5 nM)/G3-β10 (2.5 nM) or (B) β9-9.29 (2 nM)/PertH-β10 (20 nM). The kinetics of the single-step TEC assays are compared to two different conditions pre-equilibrated with HER2: antibody fusions (gray circles), or antibody fusions and Δ11S (blue squares). The difference between the pre-equilibrated solutions indicate the kinetics of binding between antibodies and HER2 and between the peptides and Δ11S. Δ11S lysate was diluted 1:20 and Nano-Glo substrate was 10 μM in all experiments.