Table 2.

Comparison of structurally equivalent residues involved in catalysis in pols β and μ

Pol β	Function	Pol μ	Function
Ser180	Binds β/γ phosphate	Gly320	Binds β phosphate
Arg183	Binds β phosphate	Arg323	Binds β phosphate
Arg149	Binds γ phosphate	Lys325	Binds γ phosphate
Gly189	Binds γ phosphate	His329	Binds γ phosphate
Asp190	Metal coordination	Asp330	Metal coordination
Asp192	Metal coordination	Asp332	Metal coordination
Arg254	Stabilizes Asp256 and PTa	Arg416	Stabilizes Asp418 and PT
Asp256	Coordinates PT and Mec b	Asp418	Coordinates PT and Mec
Phe272	Modulates Arg258/Asp192	Trp434	Stabilizes sugar of PT
Asp276	Stabilizes NTc base	Lys438	Stabilizes NT base

^aPT Primer terminus

^bMe_c Catalytic metal

^cNT Incoming nucleotide