Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 15;7:8145. doi: 10.1038/s41598-017-08414-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Receiver Operating Characteristic (ROC) curves for binder discrimination. ROC curves using Rosetta interface score of the top-scoring model as the classifier for (a) local refine, and (b) local dock. The native cognate antibody–antigen interaction pairs are true positives. ROC curves computed using four additional potentials: DFIRE2, FIREDOCK.AB, OPUS_PSP, and ZRANK2 are shown for comparison. The bottom right corner of the plot shows the area under the curve (AUC) for Rosetta bound (blue), unbound (red), and homology (green) complexes compared to the other potentials.