Table 2.

Interface metrics for cognate and non-cognate models generated using local refine and local dock.

Method	Metric	Crystal structure	Bound		Unbound		Homology
			Cognate	Non-cognate	Cognate	Non-cognate	Cognate	Non-cognate
Local Refine	Interface hydrogen bonds	7.7 ± 3.3	6.9 ± 2.4	1.8 ± 1.7	3 ± 1.5	1.7 ± 1.4	2.4 ± 1.5	2.2 ± 1.5
	Buried unsat. interface polar atoms	10.1 ± 4.3	10.5 ± 4.2	7.9 ± 4.2	11.2 ± 5.7	7.4 ± 4.1	8.5 ± 3.7	6.7 ± 3.6
	Surface area change upon binding (Å2)	1622 ± 290	1670 ± 299	1212 ± 317	1467 ± 321	1187 ± 332	1351 ± 337	1148 ± 322
Local Dock	Interface hydrogen bonds	7.7 ± 3.3	6 ± 3	3.2 ± 1.8	3.1 ± 2.1	3.4 ± 1.8	3 ± 1.6	3.2 ± 1.9
	Buried unsat. interface polar atoms	10.1 ± 4.3	11.7 ± 3.7	8.4 ± 3.7	9.2 ± 4	8.3 ± 3.5	8.4 ± 3.5	7.8 ± 3.3
	Surface area change upon binding	1622 ± 290	1636 ± 290	1309 ± 258	1394 ± 316	1328 ± 251	1332 ± 213	1292 ± 265