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. 2017 Aug 9;12:5733–5743. doi: 10.2147/IJN.S140939

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© 2017 Li et al. This work is published and licensed by Dove Medical Press Limited

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HA as potential target of Se@OTV.

Notes: (A) Comparisons of SeNP, OTV, and Se@OTV behavior in inhibition of influenza virus-induced aggregation of chicken erythrocytes. (B) NA-inhibition assay, performed utilizing NAs from H1N1 virus. Influenza virus NA activity was determined by quantifying fluorescence. The combination concentration of Se in Se@OTV was 125 µM. The combination concentration of OTV in Se@OTV was 0.3 nM. The concentration of free SeNPs was 1 mM. The concentration of free OTV was 1 nM. Bars with different characters are statistically different at *P<0.05 or **P<0.01 level.

Abbreviations: HA, hemagglutinin; NA, neuraminidase; SeNP, selenium nanoparticle; OTV, oseltamivir; Se@OTV, OTV SeNPs.