Table 3.
K i (inhibitory constant) and IC50 (50% inhibition constant) values for the inhibition of N1, N2, CpNA, and StrepNA.
| 7a | 7b | 8b | eqPO3H | |
|---|---|---|---|---|
| N1 K i | 1.62 (1.08–2.27) | — | — | — |
| N1-His275Tyr K i | 2.07 (1.63–2.62) | — | — | — |
| N2 K i a | 2.47 (1.95–3.14) | 33.5 (26.0–43.1) | 88.1 (72.8–107) | 103 (82.6–128) |
| N2 IC50 | 8.86 (6.99–11.3) | 120 (93.0–155) | 316 (260–384) | 368 (296–458) |
| CpNA IC50 | 37.5 (31.2–45.0) | — | — | 320 (221–460) |
| StrepNA IC50 | 3.74 (2.56–5.43) | — | — | — |
All values are given in μ m units and 95% confidence intervals are listed inside parenthesis. aInfluenza N2 K i values were estimated using the Cheng-Prusoff equation (K i = IC50/(1 + [S]/K m))23 with the N2 K m previously determined as 46.5 μ M 3. Dashes (−) indicate that inhibition was not determined.