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. 2017 Aug 15;7:8201. doi: 10.1038/s41598-017-07945-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Male β2GPI deficient mice have distinct cellular profiles in the blood and spleen following an E. coli challenge (A). Percentage of circulating platelets (CD41⁺) in peripheral blood, (B,C). Percentage of neutrophils (LY-6G⁺ and LY-6C⁺) and monocytes (CD11b^+high) in CD45⁺ leucocytes in peripheral blood, (D–F). B cells (CD19⁺), CD4 + (CD3⁺CD4⁺CD8⁻) and CD8 + (CD3⁺CD4⁻CD8⁺) T cells in CD45⁺ splenocytes. n = 4 per group, Male WT = ●, Male β2GPI^−/− (KO) = ○, “-” = saline, “ + ” = E. coli. Data represented as mean +/− SEM, Mann-Whitney *p < 0.05.