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. 2017 Aug 15;7:8200. doi: 10.1038/s41598-017-07800-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the monoclonal antibody variants used in this study. (a) Structural model of a monoclonal antibody with the constant domains coloured in grey and the variable domains in orange (VL) and light blue (VH). (b) Table summarising the number of mutations distinguishing any two mAb variants employed in this study; the VH domain is shown in the lower-left half and the VL domain in the upper-right half.