Figure 4.

Firing Stability Is Lost with Grid Pattern Realignment

(A) Rate map comparisons between split sessions, for cases with low and high grid overlap scores versus high and low firing stability.

(B) Mean correlation coefficient between firing rates of corresponding fields in sessions exhibiting remapping compared to sessions exhibiting no remapping (non-remapping mean r = 0.63 ± 0.04, remapping mean r = 0.27 ± 0.04).

(C) Plot of binned data showing mean correlation coefficient compared to the cross correlation gridness score of the zero-one zone maps (a measurement of grid realignment, irrespective of firing rates). The trend shows a positive correlation (r = 0.43, p < 0.001), indicating a larger correlation coefficient between firing rates with larger grid realignment. In short, the more stable the grid pattern, the more stable the firing rates among the fields across arena changes. Error bars indicate the SEM.

(D) Histogram of correlation coefficients between firing rates across non-remapping arenas. Correlation coefficients are seen to be skewed toward 1.

(E) Histogram of correlation coefficients between firing rates across remapping arenas. Correlation coefficients appear to be more uniform.