Table 3. Summary of DNA methylation data from Illumina 450 K array findings at chromosome 11p15.5 loci.

Imprinted region	Chromosome	Genomic location (hg19)	Case 1	Case 2	Case 3
H19 Promoter	11p15.5	2 019 079–2 019 167	GOM	Normal	Normal
IC1	11p15.5	2 019 568–2 024 126	GOM	Normal	Normal
IC2	11p15.5	2 720 463–2 722 086	LOM	LOM	LOM

Abbreviations: GOM, gain of methylation; IC1, imprinting centre 1 (H19 imprinting centre); IC2, imprinting centre 2 (KCNQ1OT1 IC); LOM, loss of methylation. Gain or loss of methylation at each probe defined as 2.5 s.d.’s from the mean of the values for control samples. Gain or loss of methylation for a region determined through examination of all imprinted probes in that region (see text for details of methods, see Supplementary Table 2 for detailed array data).