Table 1. Phenotypic features of the patients 1998101 and 2001012.
| Patient 1998101 | Patient 2001012 | |
|---|---|---|
| Age at description | 43 years | 62 years |
| Gender | Male | Female |
| Geographical origin | West Indies | Maghreb |
| Family history | ? | + |
| Mucocutaneous lesions | + | + |
| Oral papillomatosis | + | + |
| Acral keratosis | + | + |
| Trichilemmomas | + | ─ |
| Genital pigmentation | + | ─ |
| Thyroid lesions | + | + |
| Benign | + | + |
| Multinodular goiter | ─ | + |
| Adenomas | + | ─ |
| Malignant | ─ | ─ |
| Breast lesions | NA | + |
| Benign | NA | + |
| Malignant | NA | ─ |
| Digestive lesions | + | + |
| Colonic polyps | + | + |
| Hamartomas | + | + |
| Adenomas | ─ | + |
| Ganglioneuromas | ─ | ─ |
| Lipomas | ─ | ─ |
| Gastric polyps | + | + |
| Glycogenic acanthosis | + | + |
| Lipovascular lesions | + | + |
| Lipomatosis | + | + |
| Vascular lesions | + | + |
| Brain lesions | + | + |
| Macrocephaly | + | + |
| Lhermitte–Duclos | ─ | + |
| Mental retardation/autism | ─ | ─ |
| Epilepsy | ─ | ─ |
| Genitourinary lesions | + | + |
| Male | + | NA |
| Female | NA | + |
| Ovarian cyst | NA | ─ |
| Uterine fibromas | NA | + |
| PTEN-Predict Scorea | 93.3% | 85% |
| PTEN Cleveland Clinic Scoreb | 99% | 99% |