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. 2017 Aug 11;10(Suppl 1):5. doi: 10.1186/s13628-017-0037-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — 3D structure of HRAS (PDB ID: 6Q21:A). Effector region is in orange, allosteric region is in blue and the switch regions are depicted in red. The G12, G13, A59 and Q61 hotspot mutations are illustrated in red. The HVR region is partially (residues 166 to 171) present in the PDB and the figure