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HVR and sub-cellular localization of RAS. a Our structural models suggested the involvement of the RAS allosteric region and HVR in protein complex formation. According to the evidence in the literature we hypothesize that such interactions most likely occur when RAS is not anchored to the PM. Our structural models (b) recapitulate the well-established RAS interactors that host an RBrD, (c) and suggest additional interactions that regulate oncogenic RAS signaling
