Table 1.
Gene annotation in eDGAR
| All diseases | Diseases associated with multiple genes | |||
|---|---|---|---|---|
| # genesa | # associated diseasesb | # genesa | # associated diseasesb | |
| Total number | 3658 | 2672 | 2600 | 621 |
| Protein coding genes | 3628 (100%) | 2655 (100%) | 2576 (100%) | 619 (100%) |
| with PDB entry | 1682 (46.4%) | 1625 (61.2%) | 1176 (45.7%) | 512 (82.7%) |
| Membrane proteins | 1891 (52.1%) | 1644 (61.9%) | 1364 (53.0%) | 517 (83.5%) |
| Enzymes (with E.C number) | 1112 (30.7%) | 1045 (39.4%) | 688 (26.7%) | 363 (58.6%) |
| Reported in TRRUST (as TF) | 253 (7.0%) | 358 (13.5%) | 179 (6.9%) | 157 (25.4%) |
| Reported in TRRUST (as target) | 783 (21.6%) | 969 (36.5%) | 570 (22.1%) | 405 (65.4%) |
| Annotated with GO MF | 3419 (94.2%) | 2575 (97.0%) | 2419 (93.9%) | 617 (99.7%) |
| Annotated with GO BP | 3538 (97.5%) | 2619 (98.6%) | 2514 (97.6%) | 618 (99.8%) |
| Annotated with GO CC | 3576 (98.6%) | 2644 (99.6%) | 2533 (98.3%) | 618 (99.8%) |
| Associated with KEGG pathways | 2057 (56.7%) | 1868 (70.4%) | 1430 (55.5%) | 549 (88.7%) |
| Associated with REACTOME | 2278 (62.8%) | 2007 (75.6%) | 1595 (61.9%) | 563 (91.0%) |
| With physical BIOGRID interactions | 3307 (91.3%) | 2502 (94.2%) | 2346 (91.2%) | 609 (98.4%) |
| With genetic BIOGRID interactions | 351 (9.7%) | 472 (17.8%) | 259 (10.1%) | 247 (39.9%) |
| With STRING interactions | 2992 (82.5%) | 2341 (88.2%) | 2146 (83.3%) | 609 (98.4%) |
| Part of CORUM complexes | 714 (19.7%) | 706 (26.6%) | 558 (21.7%) | 340 (54.9%) |
| Part of CENSUS complexes | 696 (19.2%) | 689 (26.0%) | 501 (19.4%) | 296 (47.8%) |
| In tandem repeats | 381 (10.5%) | 448 (16.9%) | 280 (10.9%) | 234 (37.8%) |
aPercentages are computed with respect to the number of protein coding genes
bPercentages are computed with respect to the number of diseases associated with protein coding genes