Table 2.
Features shared by genes involved in the same heterogeneous or polygenic diseases
| # diseases | # pairwise relations | # protein coding genes | |
|---|---|---|---|
| Total number | 621 | 25,100 | 2576 |
| With pairs of genes: | |||
| In same cytogenetic band | 136 (21.9%) | 326 (1.3%) | 335 (13.0%) |
| In tandem repeat | 51 (8.2%) | 58 (0.2%) | 92 (3.6%) |
| In TF/target pairs | 39 (6.3%) | 81 (0.3%) | 94 (3.6%) |
| Co-regulated by the same TF (not involved in the disease) | 273 (44.0%) | 2308 (9.2%) | 626 (24.3%) |
| Sharing MF GO | 586 (94.4%) | 19,075 (76.0%) | 2369 (92.0%) |
| Sharing BP GO | 597 (96.1%) | 22,948 (91.4%) | 2502 (97.1%) |
| Sharing CC GO | 604 (97.3%) | 23,645 (94.2%) | 2519 (97.8%) |
| Sharing KEGG pathway | 349 (56.2%) | 3129 (12.5%) | 1074 (41.7%) |
| Sharing REACTOME pathway | 474 (76.3%) | 9806 (39.1%) | 1554 (60.3%) |
| Interacting in PDB | 96 (15.5%) | 207 (0.8%) | 199 (7.7%) |
| In the same CORUM complex | 86 (13.8%) | 469 (1.9%) | 225 (8.7%) |
| In the same CENSUS complex | 45 (7.2%) | 166 (0.7%) | 119 (4.6%) |
| Directly linked in STRING | 291 (46.9%) | 1535 (6.1%) | 932 (36.2%) |
| Indirectly linked in STRING | 115 (18.5%) | 4355 (17.4%) | 1346 (52.3%) |
| Directly linked in BIOGRID (physical interaction) | 250 (40.3%) | 944 (3.8%) | 799 (31.0%) |
| Indirectly linked in BIOGRID (physical interaction) | 160 (25.8%) | 5228 (20.8%) | 1607 (62.4%) |
| Directly linked in BIOGRID (genetic interaction) | 9 (1.4%) | 13 (0.1%) | 19 (0.7%) |
| Indirectly linked in BIOGRID (genetic interaction) | 25 (4.0%) | 45 (0.2%) | 62 (2.4%) |