Fig A6.

Alterations in the Wnt-β catenin pathway. (A) Oncoprint of somatic alterations in Wnt-β catenin pathway genes. Fifteen percent of patients harbor a somatic alteration in one of the genes listed. (B) Mutations in APC, CTNNB1 and RNF43. APC alterations are primarily deletions and truncating mutations predicted to inactivate the protein. CTNNB1 alterations are primarily hotspot N-terminal missense mutations reported to prevent phosphorylation and degradation of the protein product β catenin.