FigA 8.

MMR/MSI mutation signatures in hypermutated tumors. K-means clustering of mutations/Mb (mut/Mb) across all 504 tumors identified two distinct clusters: cluster1 with Mutations/Mb10. The latter represents hypermutated tumors. Tumors in the hypermutated group correspond to the 8 patients with > 20 MSK-IMPACT mutations represented in Figure A5B. Mutational signature decomposition analysis for hypermutated tumors and control non-hypermutated tumors with >8mutation/Mb revealed a high contribution of MMR/MSI signatures to all hypermutated tumors, as measured by proportion of mutations attributed to a specific signature across 30 different mutational signatures.^22,33