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The systemic injection of CB1 and CB2 receptor antagonists do not block the antinociceptive effects of PNU282987 in the formalin test. CB1 receptor antagonist rimonabant (3 mg/kg, i.p.) and CB2 receptor antagonist SR144S28 (3 mg/kg, i.p.) do not block the antinociceptive effects of PNU282987 (10 mg/kg, s.c.) in both (A) phase I and (B) phase II. Data reflect the mean ± S.E.M. of 6–8 animals for each group. * P < 0.05, significantly different from its corresponding control group.
