Table I.

Influenza therapeutics and interventions

Agent	Investigational Phasea	Target	References
Peramivir IV	Phase II-III	Influenza neuraminidase	30–49
Zanamivir IV	Phase II	Influenza neuraminidase	8,17,28, 50–53
CS-8958	Phase III	Influenza neuraminidase	54–60
T-705	Phase III	Influenza polymerase	61–64, 67–69
Cyanovirin-N	Experimental	Influenza hemagglutinin	70–73
DAS181	Phase I	Host sialic acid residues	75–80
Nitazoxanide	Experimental	Influenza hemagglutinin	83
siRNA	Experimental	Host or viral genes	88–94
Combination therapy	Phase I & II	Influenza neuraminidase and polymerase	114–117
Cox inhibitors	Experimental	Cox-2 enzyme	109–111
PPAR agonists	Experimental	Peroxisome proliferator-activated receptor	114–117

^aPhase of drug evaluation for use against influenza.