Table 3. . ATP-binding cassette transporters that can transport first- and second-line drugs used in high-grade osteosarcoma chemotherapy.
| |
ABCB1 (MDR1) |
ABCC1 (MRP1) |
ABCC2 (MRP2) |
ABCC3 (MRP3) |
ABCC4 (MRP4) |
ABCC5 (MRP5) |
ABCC6 (MRP6) |
ABCC10 (MRP7) |
ABCC11 (MRP8) |
ABCG2 (BCRP) |
| Doxorubicin |
|
|
|
|
|
|
|
|
|
|
| Methotrexate |
|
|
|
|
|
|
|
|
|
|
| Cisplatin |
|
|
|
|
|
|
|
|
|
|
| Ifosfamide |
|
|
|
|
|
|
|
|
|
|
| Vinca alkaloids |
|
|
|
|
|
|
|
|
|
|
| Taxanes |
|
|
|
|
|
|
|
|
|
|
| Gemcitabine |
|
|
|
|
|
|
|
|
|
|
| Etoposide |
|
|
|
|
|
|
|
|
|
|
| Bleomycin |
|
|
|
|
|
|
|
|
|
|
| Dactinomycin (actinomycin D) |
|
|
|
|
|
|
|
|
|
|
| Cyclophosphamide |
|
|
|
|
|
|
|
|
|
|
| Carboplatin |
|
|
|
|
|
|
|
|
|
|
| Topotecan |
|
|
|
|
|
|
|
|
|
|
| Irinotecan (SN-38) |