Table 4. . Drug metabolizing enzymes involved in detoxification and/or activation of second-line chemotherapeutic drugs that have been used in high-grade osteosarcoma.
|
Drug metabolizing enzymes involved in: |
||
|---|---|---|
| Drug | Detoxification/inactivation | Activation |
| Vinorelbine |
CYP2D6; CYP3A4 GSTM1 |
|
| Vinblastine |
CYP2D6; CYP3A4; CYP3A5 GSTM1 |
|
| Docetaxel |
CYP1B1; CYP2A4; CYP2C8 GSTP1 |
|
| Paclitaxel |
CYP1B1; CYP2C8; CYP2C9; CYP3A4; CYP3A5; CYP3A7; CYP19A GSTP1 |
|
| Gemcitabine |
GSTT1 |
|
| Etoposide |
CYP1A2; CYP2C8; CYP2C9; CYP2E1; CYP3A4; CYP3A5 GSTs UGTs |
|
| Bleomycin |
GSTs |
|
| Dactinomycin (actinomycin D) |
CYP1A1; CYP1A2 |
|
| Cyclophosphamide |
CYP2A6; CYP2C18; CYP2C19; CYP3A4; CYP3A4; CYP3A7 GSTs |
CYP2A6; CYP2B6; CYP2C8; CYP2C9; CYP2C19; CYP3A4; CYP3A5 |
| Carboplatin |
GSTP1 |
|
| Topotecan |
CYP3A4 |
|
| Irinotecan | CYP2B6; CYP3A4; CYP3A5; CYP3A7 UGT1A1; UGT1A3; UGT1A4; UGT1A6; UGT1A8; UGT1A9; UGT1A10 |
CYP3A4; CYP3A5 |