Table 4. . Influence of haplotype on the effect of chloride in protecting GSTZ1-1 from inactivation by dichloroacetate.
Haplotype | EC50 mM | Inactivation half-life, h without Cl- | Inactivation half-life, h with 38 mM Cl- |
---|---|---|---|
EGT/EGT |
15 ± 3.1 (3) |
0.53, 0.49 |
5.73, 5.02 |
KRT/EGT |
36 ± 2.2 (3) |
0.38, 0.38 |
2.66, 2.37 |
EGM/EGM | 16.9 | – | 5.55 |
EC50 is the concentration of chloride that protected half the cytosolic GSTZ1 from inactivation following incubation for 2 h with Na DCA, 0.5 mM.