Table 2. . Inverse-variance weighted, Mendelian randomization–Egger and median-based estimators for the association between low-density lipoprotein cholesterol levels and proportional low-density lipoprotein cholesterol response to statin therapy.

Analysis method	Full list of 59 variants		42 variants primarily associated with LDL-c
	Beta (SE)	p-value	Beta (SE)	p-value
Inverse-variance weighted	0.054 (0.006)	8.4 × 10-12*	0.032 (0.010)	2.1 × 10-3*
MR–Egger: slope	0.089 (0.010)	1.0 × 10-11*	0.044 (0.018)	1.7 × 10-2*
MR–Egger: intercept	-0.003 (0.001)	7.6 × 10-5*	-0.001 (0.001)	0.40
Weighted median	0.070 (0.011)	4.2 × 10-8*	0.043 (0.015)	6.4 × 10-3*
Penalized weighted median	0.051 (0.011)	2.8 × 10-5*	0.043 (0.015)	6.8 × 10-3*

Beta's (SE) given as differential LDL-c response to statin therapy per standard deviation increase in LDL-c levels. The MR–Egger intercept term provides a formal test of directional pleiotropy.

*Statistically significant results, using a p-value threshold of 0.05.

LDL-c: Low-density lipoprotein cholesterol; MR: Mendelian randomization; SE: Standard error.