Figure 9.

A, The drug penetration averaged along the depth direction to give an indication of the average drug signal in each group as a function of time. B, A comparison of the drug penetration as a function of distance to the nearest vessel at the 60min time point. The drug penetration is nearly homogeneous up to 17.5µm in each case, but there is a significant difference between the 20min FUS+HT group and the 10x 30s FUS+HT group up to 10µm. At each penetration distance examined here, the 20min FUS+HT group showed significantly more DOX signal than unheated controls. Significance was evaluated using one-way ANOVA following by a multiple comparison test in Matlab between the 30s FUS+HT and unheated controls at each time point, (*) p < 0.05, (**) p < 0.01.