Table 4.

Major toxicities of apatinib dosing

Toxicity	Total (%)	Grades 3/4 (%)	Dosage reduction (%)	Discontinuation (%)
Hand-foot syndrome	32 (51.6)	10 (16.1)	2 (20.0)	1 (33.3)
Hypertension	13 (21.0)	7 (11.3)	2 (20.0)	1 (33.3)
Proteinuria	15 (24.2)	7 (11.3)	2 (20.0)	1 (33.3)
Hepatic injury	12 (19.4)	5 (8.1)	0 (0.0)	0 (0.0)
Fatigue	9 (14.5)	3 (4.8)	2 (20.0)	0 (0.0)
Esophagitis	4 (6.5)	3 (4.8)	2 (20.0)	0 (0.0)
Nausea/vomiting	9 (14.5)	2 (4.8)	0 (0.0)	0 (0.0)