Fig. 1.

Interferon stimulated gene expression in the HCV infected liver. RNA was extracted from biopsies sampled from the 8 segments of the explanted liver of patients diagnosed with chronic hepatitis C (Genotype 1 [Gt1] n = 13; Genotype 3 [Gt3] n = 7 and Genotype 2 [Gt2] n = 1) and from a single biopsy collected from 6 normal controls. The mRNA levels for ISG15 (A), IFI27 (B), RSAD2 (C) and HTATIP2 (D) were quantified and normalized with an internal GAPDH mRNA expression referent. Data are presented for each biopsy sample showing the mean expression levels ± SD and the average values for the total liver denoted in the right-hand panel along with controls (red). The dashed horizontal line denotes the mean expression of normal biopsies.