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. Author manuscript; available in PMC: 2017 Sep 2.
Published in final edited form as: Nature. 2017 Feb 22;543(7643):113–117. doi: 10.1038/nature21405

Extended Data Figure 10. Locus-promoter configuration controls CAR protein expression and transcriptional response upon CAR T cell activation.

Extended Data Figure 10

a, Left, representative histogram of the CAR expression 5 days after its vectorization into T cells. Right, relative CAR MFI (1 =MFI at 0 h) after CAR T cells being activated 1, 2 or 4 times on CD19+ target cells over a 48 h period. b, Comparison between CAR MFI and CAR RNA relative level before stimulation (n = 3 independent experiment on 3 donors).