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. 2017 Aug 15;9:85. doi: 10.1186/s13148-017-0386-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Methylation profile plot from GP1BB and ZAP70. For each group of samples, each line represents the methylation mean for each position. Asterisks indicate a statistical significance as calculated by the Kruskal-Wallis test. ZAP70 and GP1BB, together with H19, EPHX3, and MIR193 (see Additional file 1 for the methylation profile of all targets), revealed a fluctuating behavior among the various CpGs evaluated. The gap between normal and OSCC remained mostly the same (Kruskal-Wallis P values were < 0.05), but the absolute values changed conspicuously among different positions investigated